IMB’s Biomolecular Nuclear Magnetic Resonance (NMR) Facility makes the powerful technique of NMR spectrometry accessible to our research and industry clients. The facility comprises a 600 MHz spectrometer with a cryoprobe and autosampler, and a 500 MHz spectrometer, equipped with a robotic sample changer. In addition to the institute’s extensive NMR infrastructure, IMB researchers also have access to a 900 MHz spectrometer equipped with a cryoprobe and sample changer, making it the most powerful state-of-the-art NMR spectrometer in Australia. This instrument is located at UQ and is an instrument of the Queensland NMR Network.

The available instrumentation is particularly useful for the determination of high-resolution structures of biological macromolecules such as proteins, as well as characterisation of protein/ligand interactions; determination of molecular size and oligomerisation state; investigation of dynamic properties; and metabonomic studies of various biofluids.

Key discoveries made in 2013 using the facility include structural characterisation of an oxytocic plant peptide that modulates the human oxytocin/vasopressin receptor, and of numerous venoms, including those from cone snails, snakes and scorpions; and the determination of self-association properties of cyclic peptides.

The facility is available on a user-pays system to researchers from a range of scientific disciplines across UQ. The facility also holds collaborations with researchers from other Australian universities as well as several international collaborations, most recently with scientists from Austria, China, and the US.

 

Facility contacts

Facility Manager: Dr Peta Harvey
Phone: +61 7 334 62925
Email: peta.harvey@imb.uq.edu.au

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