IMB Seminar Series - The Genes in our Food, 10 Feb
12pm-1pm, 10 February, QBP Auditorium (Building 80)
Professor David Hume
Director of The Roslin Institute and Research Director,
Royal (Dick) School of Veterinary Studies,
University of Edinburgh
Genes in our Food
Two technology revolutions in genome sciences, next generation sequencing and genome-editing, have made it possible to start to understand the relationships between genotype and phenotype in molecular terms and herald an era of predictive biology. For non-coding control elements in the genome, which are the major targets of variation within and between species, analysis of the function of sequence variation is not straightforward. We must first identify those elements of the non-coding DNA that are functional and sensitive to variation.
Professor Hume will firstly introduce some of the recent work of the FANTOM Consortium, which has contributed to functional annotation of the human and mouse genomes. He will then talk about progress in the use of transcriptomic data to annotate the genomes of major livestock species, notably pig, chicken and sheep, and the ways in which coexpression clustering can suggest functions of genes that currently lack annotation. Finally, he will discuss the applications of genomic technologies to produce sustainable improvements in livestock productivity and the use of large animals as model organisms.
Watch the full seminar
David Hume graduated with 1st Class Honours in biochemistry and a PhD from ANU. As a postdoctoral fellow in the Dunn School of Pathology in Oxford, he carried out extensive studies of the distribution of macrophages in tissues. This has remained his research focus.
In 1988, he joined the Centre for Molecular Biology and Biotechnology, which grew to become the IMB. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation
In 2007, he was appointed Director of The Roslin Institute. He continues to run a large research group, and has extended his interest in macrophage biology and comparative genomics to major livestock species.
David’s work on macrophage biology was recognized in 2012 by the Society for Leukocyte Biology with the Bonazinga Medal. He has been elected to Fellowships in the Royal Society of Edinburgh, the Academy of Medical Sciences and the Royal Society of Biology.
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