<b>Associate Professor Rohan Teasdale</b><br>
Group Leader, Cell Biology and Molecular Medicine Division<br>
Investigator, Centre for Pain Research<p>
P: +61 7 3346 2056<br>
E: r.teasdale@imb.uq.edu.au<p>
<b>Keywords</b><br>
- infectious disease<br>
- Salmonella bacteria<br>
- Alzheimer's disease<br>
- Parkinson's disease
Associate Professor Rohan Teasdale
Group Leader, Cell Biology and Molecular Medicine Division
Investigator, Centre for Pain Research

P: +61 7 3346 2056
E: r.teasdale@imb.uq.edu.au

Keywords
- infectious disease
- Salmonella bacteria
- Alzheimer's disease
- Parkinson's disease

Endosomal dynamics and pathogen invasion

The movement of the thousands of distinct membrane proteins between the cell surface and intracellular compartments represents a critical cellular process as it controls the organisation of cells in tissues and the communication between cells and their environment. The success of this process depends on the regulated sorting and trafficking of proteins within the highly dynamic intracellular endosomal compartments of the cell.

Defects in endosomal trafficking are linked to many human diseases including various neurodegenerative diseases, cancers and metabolic diseases. Our long-term research program is focused on the discovery and characterisation of novel endosome associated proteins and defining their molecular function in endosomal trafficking pathways.

For example, our prior basic research into the characterisation of retromer, which is a central regulator of early endosome protein trafficking, recently enabled us to provide the first molecular insights into how its function is modified in disease. Genetic mutations in retromer have recently been associated with progressive neurological diseases including Parkinson’s disease. We have determined the molecular changes that occur in endosomal trafficking to cause these disease states.

Numerous infectious pathogens depend on their ability to manipulate endosome trafficking, specifically through host-pathogen interactions, to successfully invade the host. We are currently investigating the molecular details of these pathways and how they are modulated in response to infection with a number of pathogens including Salmonella, a leading cause of human gastroenteritis; chlamydia, a major sexually transmitted disease; and Group A Streptococcus, a common bacterial cause of human mortality through a range of conditions.

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Research training opportunities

Please see IMB's postgraduate website for more information. 

Key publications

View more publications by Associate Professor Teasdale via Pubmed or via UQ Reseachers. 

Kerr, M.C., Wang, J.T.H., Castro, N., Hamilton, N.A., Town, L., Brown, D.L., Meunier, F.A., Brown, N.F., Stow, J.L., and Teasdale, R.D. (2010). Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO Journal 29: 1331-1347.

Wang, J.T., Kerr, M.C., Karunaratne, S., Jeanes, A., Yap, A.S., and Teasdale, R.D. (2010). The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. PLoS One 5: e13763.

Kerr, M.C., and Teasdale, R.D. (2009). Defining macropinocytosis. Traffic 10: 364-371.

Hamilton, N., and Teasdale, R.D. (2008). Visualizing and Clustering High Throughput Sub-cellular Localization Imaging. BMC Bioinformatics 9: 81.

Sprenger, J., Fink, J.L., Karunaratne, S., Hanson, K., Hamilton, N., and Teasdale, R.D. (2007). LOCATE: A Mammalian Protein Subcellular Localization Database. Nucleic Acids Research 36(Database issue): 230-233.

Group contacts

Dr Andrea Bugarcic
Research staff
+61 7 334 62031
+61 7 334 62332
a.bugarcic@imb.uq.edu.au
Ms Genevieve Kinna
Research staff
+61 7 334 62031
+61 7 334 62332
g.kinna@imb.uq.edu.au
Mr Wei Teo
Research higher degree student
+61 7 334 62332
+61 7 334 62336
w.teo@imb.uq.edu.au
Mr Jordan Follett
Research higher degree student
+61 7 334 62332
+61 7 334 62336
j.follett@imb.uq.edu.au
Ms Xiaying Qi
Research higher degree student
+61 7 334 62332
+61 7 334 62336
x.qi@imb.uq.edu.au
Dr Zhe Yang
Research staff
+61 7 334 62031
+61 7 334 62332
z.yang@imb.uq.edu.au
Dr Markus Kerr
Research staff
+61 7 334 62031
+61 7 334 62332
m.kerr@imb.uq.edu.au
Associate Professor Rohan Teasdale
Group leader
+61 7 334 62056
r.teasdale@imb.uq.edu.au
 

 

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