<h4><b>Professor Melissa Little</h4></b><p>
<b>NHMRC Senior Principal Research Fellow</b><p>
Head, Genomics of Development and Disease Division<br><p>
P: +61 7 3346 2054<br>
E: m.little@imb.uq.edu.au<p>
<b>Keywords</b><br>
- kidney development<br>
- kidney disease<br>
- kidney regeneration<br>
- stem cell biology<br>
- embryonic stem cells<br>
- adult stem cells

Professor Melissa Little

NHMRC Senior Principal Research Fellow

Head, Genomics of Development and Disease Division

P: +61 7 3346 2054
E: m.little@imb.uq.edu.au

Keywords
- kidney development
- kidney disease
- kidney regeneration
- stem cell biology
- embryonic stem cells
- adult stem cells

Visit the Little Lab website for more information.

Kidney development, damage, repair and regeneration

Chronic kidney disease affects more than 4000 Australian adults each year, costing the Australian health system in excess of $2 billion per year. Once a patient has reached end-stage renal failure, chronic kidney disease can only be treated with dialysis or transplantation. This, coupled with the rising rate of chronic kidney disease, is creating an urgent need for scientists to develop novel therapeutic treatments to improve quality of life for patients affected by the disease.

Our laboratory is known internationally for defining the genes involved in normal kidney development and integrating this information with an understanding of how the adult kidney responds to damage. We hope to develop novel approaches to the diagnosis and treatment of both acute and chronic kidney disease and encourage the kidneys to heal themselves.

The risk of kidney failure during our lives is linked to what happens during the development of our kidneys. We have now shown that a mild change in the amount of oxygen available during development is enough to affect eventual kidney structure and function and that this depends upon the timing, severity and duration of the insult. We have also been able to visualise the developing kidney across time to such a high degree of resolution that we can now build mathematical models predicting the outcome in a given circumstance. This will improve our understanding of how variation in kidney development comes about and possibly how we might be able to alter this.

Make a difference to Professor Little's research by donating today.

Key Publications

View more publications by Professor Little via PubMed.

Hendry C*, Vanslambrouck J*, Ineson J, Suhaimi N, Takasato, M, Rae F, Little MH. Evidence for direct transcriptional reprogramming of adult cells to nephron progenitors. JASN (accepted April 2013) (*joint first authors).

Phua Y, Martel N, Pennisi DJ, Little MH and Wilkinson L. Distinct sites of renal fibrosis in the Crim1 mutant mice arise from multiple cellular origins. J Pathology (2013) 229(5):685-96.

Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. (2012) Development 139(10):1863-73.

Wilkinson L, Kurniwan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH. Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice. (2012) J Pathology 227(4):499-510. (This article featured in the Journal Club of Kidney International (2012) 82, 3–4.)

Funding

NHMRC, ARC, HFSP, NIH, Rosamond Siemon Postrgraduate Scholarship, EU FP7 consortium.

Lab contacts

Mr Brandon Binnie
Honours student
+61 7 334 62347
+61 7 334 62347
brandon.binne@uqconnect.edu.au
Mr Ali Ju
Research staff
+61 7 334 62343
+61 7 334 62347
a.ju@imb.uq.edu.au
Ms Barbara Maier
Research higher degree student
+61 7 334 62343
+61 7 334 62347
b.maier@imb.uq.edu.au
Mr Han Chiu
Research staff
+61 7 334 62347
h.chiu@imb.uq.edu.au
Mrs Pamela Kairath Oliva
Research higher degree student
+61 7 334 62343
+61 7 334 62055
p.kairatholiva@imb.uq.edu.au
Ms Norseha Mohamed Suhaimi
Research staff
+61 7 334 62343
+61 7 334 62347
m.mohamedsuhaimi@imb.uq.edu.au
Dr Alexander Combes
Research staff
+61 7 334 62060
+61 7 334 62343
a.combes@imb.uq.edu.au
Dr Joan Li
Research staff
+61 7 334 62055
+61 7 334 62343
joan.li@imb.uq.edu.au 
Dr Minoru Takasato
Research staff
+61 7 62055
+61 7 334 62343
m.takasato@imb.uq.edu 
Ms Pei Er
Research staff
+61 7 334 62343
+61 7 334 62347
p.er@imb.uq.edu.au
Professor Melissa Little
Laboratory head
+61 7 334 62054
m.little@imb.uq.edu.au
Dr Jessica Vanslambrouck
Research staff
+61 7 334 62060
+61 7 334 62343
j.vanslambrouck@imb.uq.edu.au
Ms Kylie Georgas
Research staff
+61 7 334 62065
+61 7 334 62343
k.georgas@imb.uq.edu.au
   

 

 

On this site