<b>Professor Kirill Alexandrov</b><br>
Group Leader, Cell Biology and Molecular Medicine Division<br>
Investigator, Breakthrough Science Program in Algal Biomedicine<p>
P: +61 7 3346 2017<br>
E: k.alexandrov@imb.uq.edu.au<p>
<b>Keywords</b><br>
- biosensors<br>
- point of care diagnostics<br>
- cancer diagnostics<br>
- diagnostics of infectious diseases
Professor Kirill Alexandrov
Group Leader, Cell Biology and Molecular Medicine Division
Investigator, Breakthrough Science Program in Algal Biomedicine

P: +61 7 3346 2017
E: k.alexandrov@imb.uq.edu.au

Keywords
- biosensors
- point of care diagnostics
- cancer diagnostics
- diagnostics of infectious diseases

Molecular engineering: better tools, better science, better life

Human civilisation is built on exploiting and manipulating biological systems, from the most simple to the most complex. Animal cloning, sequencing and synthesis of complete genomes demonstrated the technical capacity of modern biotechnology to modify and replicate living organisms. The next step in this development is the knowledge-based design of biological systems. While the classical engineering-driven designs of devices is based on the first principles of physics and mathematics, the lack of quantitative descriptions of living systems makes their redesign an empirical and unpredictable process.

Our research is focused on filling this technological gap by developing new methods for rapid in vitro synthesis and engineering of proteins and protein-based machines. These methods are vital in biotechnology, as the ability to produce and analyse proteins determines the cost and speed of discovering and creating new diagnostic methods, vaccines and drugs.

In pursuing our interest in artificial sensory systems we have developed a range of synthetic signal transduction and amplification cascades for use in organism engineering and in vitro diagnostics. We have also developed a novel approach for synthesis of polypeptides with non-native and improved properties for use in human health and industrial applications.

Notably, in 2015 we partnered with spin-off UK/Australian company Molecular Warehouse ltd to bring our biosensor technology into the everyday clinical practice. Our work was recognised by the 2015 Innovator Award by the National Breast Cancer Foundation. The application of our biosensor technology to diagnose infectious diseases is supported by the Grand Challenges Explorations Grant from the Bill and Melinda Gates foundation.

Make a difference to Professor Alexandrov's research by donating today.

Research training opportunities

Please see IMB's postgraduate website for more information. 

Key publications

View more publications by Professor Alexandrov via Pubmed or via UQ Researchers.

Guo Z, Murphy L, Stein V, Johnston WA, Alcala-Perez S, Alexandrov K. Engineered PQQ-Glucose Dehydrogenase as a Universal Biosensor Platform. J Am Chem Soc. 2016 Aug 17;138(32):10108-11

Stein V, Alexandrov K. (2014) Synthetic protein switches: design principles and applications. Trends Biotechnol. pii: S0167-7799(14)00239-X.

Stein V, Alexandrov K. (2014) Protease-based synthetic sensing and signal amplification. Proc Natl Acad Sci USA. 111(45):15934-9

Mureev, S., Kovtun, O., Nguyen, U.T.T., and Alexandrov, K. (2009). Species-independent translational leaders enable the rapid development of novel cell-free expression systems. Nature Biotechnology 27: 747-752.

Group contacts

Professor Kirill Alexandrov
Group leader
+61 7 334 62334
+61 7 334 62397
k.alexandrov@imb.uq.edu.au

Dr Wayne Johnston
Research staff
+61 7 334 62040
+61 7 334 62334
w.johnston@imb.uq.edu.au
Dr Viktor Stein
Research staff
+61 7 334 62040
+61 7 334 62334
v.stein@imb.uq.edu.au 

Ms Zhenling Cui
Research higher degree student
+61 7 334 62172
+61 7 334 62334
zhenling.cui@imb.uq.edu.au

Dr Sergey Mureev
Research staff
+61 7 334 62040
+61 7 334 62334
s.mureev@imb.uq.edu.au
Ms Shayli Varasteh Moradi
Research staff
+61 7 334 62172
s.varastehmoradi@uq.edu.au

Mrs Fernanda Ely
Research staff
+61 7 334 62172
f.ely@imb.uq.edu.au

Ms Hoang-Nga Nguyen
Research higher degree student
+61 7 334 62172
hoang-nga.nguyen@imb.uq.edu.au

Ms Yue Wu
Research higher degree student
+61 7 334 62172
yue.wu@imb.uq.edu.au
Mr Dejan Gagoski
Research higher degree student
+61 7 334 62172
+61 7 334 62334
d.gagoski@imb.uq.edu.au
Ms Marinna Nilsson
Research staff
+61 7 334 62172
0438 384 893
m.nilsson@imb.uq.edu.au 
 
Dr Zhong Guo
Research staff
+61 7 334 62040
+61 7 334 62334
z.guo@imb.uq.edu.au
Mr Jake Parker
Research higher degree student
+61 7 334 62172
j.parker@imb.uq.edu.au
 

 

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