<h5><b>Professor Jennifer L Martin</h5></b><br>
<b>NHMRC Fellow</b><p>
<b>ARC Australian Laureate Fellow 2010-2014</b><p>

Group Leader, Chemistry and Structural Biology Division<br>
Co-Director, Breakthrough Science Program in Biomembrane Design<br>
Investigator, Centre for Superbug Solutions<p>
P: +61 7 3346 2016<br>
E: j.martin@imb.uq.edu.au<br>
T: @JennyMartin_UQ<p>
- bacterial infection<br>
- inflammation<br>
- diabetes<br>
- drug discovery<br>
- superbugs<br>
- antibacterials<br>
- antibiotics<br>
- protein crystallography
Professor Jennifer L Martin

NHMRC Fellow

ARC Australian Laureate Fellow 2010-2014

Group Leader, Chemistry and Structural Biology Division
Co-Director, Breakthrough Science Program in Biomembrane Design
Investigator, Centre for Superbug Solutions

P: +61 7 3346 2016
E: j.martin@imb.uq.edu.au
T: @JennyMartin_UQ

- bacterial infection
- inflammation
- diabetes
- drug discovery
- superbugs
- antibacterials
- antibiotics
- protein crystallography

For more information about Professor Jennifer L Martin's lab go to the Martin lab website

Antibiotic discovery, understanding insulin signalling, protein structure and drug design

Our research aims to understand the role of proteins in disease and to develop novel drugs that target these disease-causing proteins. We use biophysical techniques including protein crystallography; small-angle scattering; chemical cross-linking; mass spectrometry and structure-based approaches for inhibitor design.

Of particular interest are the master regulators of virulence in bacteria, the Dsb proteins. These are key targets for the development of antibacterial agents that block bacterial pathogens from causing disease. We have developed a library of Dsb protein structures from human pathogens as a resource for structure-based drug design.

We are also working in collaboration with other leading Australian researchers to develop inhibitors of these proteins using a multi-pronged approach, including fragment screening, in silico screening and peptidomimetic design. From these investigations, we plan to develop peptidomimetics and small molecules to treat infections caused by multidrug-resistant bacteria and combat the growing global threat of antimicrobial resistance.

Our lab also works on diabetes, focusing on proteins that that support membrane trafficking in cells to help regulate blood glucose levels in response to insulin signalling. Through collaborations in Australia and the US we are unravelling the dynamic interactions induced by insulin binding to muscle and fat cells. This research aims to identify what goes wrong in diabetes, and in the long term may lead to new therapeutics to treat this devastating disease.

Most recently, we have implemented facilities and methodologies to tackle challenging structural biology targets including integral membrane proteins and membrane protein complexes.

Make a difference to Professor Martin's research by donating today. 

Research in the news

16 January 2014 - A case for a university happiness ranking. Nature: News and Comment

25 February 2014Proteins to plastics: chemistry as a dynamic discipline. The Conversation

8 October 2013 Bread, beer and boxtox: the science behind the 2013 Nobel Prize for Medicine, The Conversation

Watch Jenny's talk from the 2013 UQ Research Week BrisScience public lecture (16 September) on 'How are new medicines discovered?'

Research training opportunities

Please see IMB's posgraduate website for more information. 

Key publications

View more publications by Professor Martin via Pubmed or via UQ Researchers.

Duprez W, Lakshmanane P, Halili M, Lindahl F, Reid R, Fairlie D, Martin JL. (2014). Peptide Inhibitors of the Escherichia coli DsbA Oxidative Machinery Essential for Bacterial Virulence. Journal of Medicinal Chemistry ePub Dec 3 2014.

Adams LA, Sharma P, Mohanty B, Ilyichova O, Mulcair M, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Home J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B, Simpson JS, Scanlon MJ. (2014). Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA. Angewandte Chemie. ePub Dec 30 2014. 

Ireland PM, McMahon RM, Marshall LE, Halili M, Furlong E, Tay S, Martin JL, Sarkar-Tyson M. (2014). Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo. Antioxidants & Redox Signaling. 20: 606-17.

Kurth F, Duprez W, Premkumar L, Schembri MA, Fairlie DP, Martin JL. (2014). Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand. Journal of Biological Chemistry 289:19810-22.

Christie, M.P., Whitten, A.E., King, G.J., Hu, S.-H., Jarrott, R.J., Chen, K.-E., Duff, A.P., Callow, P., Collins, B.M., James, D.E., and Martin, J.L. (2012). Low resolution solution structures of Munc18:Syntaxin complexes indicate an open binding mode driven by Syntaxin N-peptide binding. Proceedings of the National Academy of Sciences USA 109: 9816-9821.

Hu, S.H., Christie, M.P., Saez, N.J., Latham, C.F., Jarrott, R., Lua, L.H., Collins, B.M., and Martin J.L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences USA 108: 1040-1045.

Heras, B., Shouldice, S.R., Tokrina, M., Scanlon, M.J., Schembri, M., and Martin, J.L. (2009). Dsb proteins and bacterial pathogenicity. Nature Reviews Microbiology 7: 215-225.

Group contacts

Mr Karl Byriel
Support staff
+61 7 400 209 186
+61 7 334 62929
Dr Shu-Hong Hu
Research staff
+61 7 334 62020
+61 7 334 62323
Professor Jenny Martin
Group leader
+61 7 334 62016
+61 7 334 62323
Dr Hassan Choudhury
Research staff
+61 7 334 62020
+61 7 334 62323
Mr Russell Jarrott
Research staff
+61 7 334 62323
+61 7 334 62327
Dr Roisin McMahon
Research staff
+61 7 334 62022
+61 7 334 62323
Ms Signe Christensen
Research higher degree student
+61 7 334 62323
+61 7 334 62327
Dr Gordon King
Research staff
+61 7 334 62020
+61 7 334 62323
Miss Kuan Yuen (Eunice) Poon
Masters student
+61 7 334 62323
+61 7 334 62327
Dr Wilko Duprez
Research staff
+61 7 334 62323
+61 7 334 62327
Mr Fabian Kurth
Research staff
+61 7 334 62323
+61 7 334 62327
Dr Patricia Walden
Research staff
+61 7 334 62022
+61 7 334 62323