<b>Dr Joseph Powell</b><br>
Group Leader, Genomics of Development and Disease Division, IMB<br>
Joint appointment, Queensland Brain Institute<p>
P: +61 7 3346 2611<br>
E: joseph.powell@uq.edu.au<p>
<b>Keywords</b><br>
- single cell sequencing<br>
- functional genomics<br>
- transcriptomics<br>
- RNA<br>
- sequencing<br>
- population genetics<br>
- medical genomics<br>
Dr Joseph Powell
Group Leader, Genomics of Development and Disease Division, IMB
Joint appointment, Queensland Brain Institute

P: +61 7 3346 2611
E: joseph.powell@uq.edu.au

Keywords
- single cell sequencing
- functional genomics
- transcriptomics
- RNA
- sequencing
- population genetics
- medical genomics

Single cell and computational genomics

The Single Cell and Computational Genomics Lab focuses on identifying how DNA sequence variants contribute to human disease. Our research involves the use of large-scale transcriptomic and DNA sequence data from both bulk tissues and single cells. By applying computational and statistical methods to this data, we aim to identify the functional mechanisms by which genetic variants contribute to disease susceptibility at a cellular level. We approach this from three related angles: What are the differences in genetic control of transcription between cell types? How does the effect of genetic variation change under different cell environmental conditions? Does the mechanism of a disease-causing genetic variant become ‘active’ at a specific point in cell developmental lineage?

Our group is committed to reproducible research practices, and where possible makes all code open-source and data publically available.

Make a difference to Dr Powell's research by donating today.

Powell group in the news

NHMRC feature: The role of genetic variation in common diseases (Jan 2017)

Why sharing scientific data is the way of the future (Jan 2017)

Awards to help researcher unlock the secrets of DNA (Jul 2016)

IMB scientist wins top Minister’s award (Jun 2016)

Scientists find 1500 'ageing' genes that could lead to new treatments (Oct 2015)

Excellence award for genetic disease research (Sep 2015)

Research training opportunities

Please see IMB's postgraduate website for more information. 

Key publications

View more publications by Dr Powell via PubMed and via UQ Researchers

Powell, J. E., Henders, A. K., McRae, A. F., Wright, M. J., Martin, N. G., Dermitzakis, E. T., Montgomery, G. W., Visscher, P. M. (2012) Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Research, 22, 456-66.

 The GIANT Consortium. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173-1186.

Powell, J. E., Visscher, P. M. and Goddard, M. E. (2010) Reconciling the analysis of IBD and IBS in complex trait studies. Nature Reviews Genetics, 11, 800-805.

Powell, J. E., Henders, A. K., McRae, A. F., Kim, J., Hemani G., Martin, N. G., Dermitzakis, E., Gibson, G., Montgomery, G. W., Visscher, P. M. (2013) Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data. PLoS Genetics, 9, e1003502.

Powell, J. E.*, McEvoy, B. P.*, Goddard, M. E. and Visscher, P. M. (2011) Human population dispersal “out of Africa” estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Research, 21, 821-829 * Joint first.

Hemani, G., Shakhbazov, K., Westra H., Esko, T., Henders, A. K., McRae, A. F., Yang, J., Gibson, G., Martin, M. G., Metspalu A., Franke, L., Montgomery, G. W., Visscher, P. M., Powell, J. E. (2014) Detection and replication of epistasis influencing transcription in humans. Nature, 508, 249-253.

Gordon, L. Joo, E. J. Powell, J. E., et al. (2012) Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Research, 22, 1395-405.

Yang, J., Loos, R. J. F., Powell, J. E., et al. (2012) FTO genotype is associated with phenotypic variability of body mass index. Nature, 490, 267-72.

Westra, H. J., et al. (2013) Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45, 1238-43.

Goldinger, A., Henders, A., McRae, A. F., Martin, N. G., Gibson, G., Montgomery, G. W., Visscher, P. M., Powell, J. E. (2013) Genetic and non-genetic variation revealed for the principal components of human gene expression. Genetics, 195, 1117-28.

The CHARGE Consortium (Powell, J. E. Joint first) The transcriptional landscape of age in human peripheral blood. Nature Communications, 16, 8670.

Powell J. E., et al. (2016) Endometriosis risk alleles at 1p36. 12 act through inverse regulation of CDC42 and LINC00339. Human Molecular Genetics, In Press.

Lloyd-Jones L. R., Holloway A., McRae A., Yang J., Small K., Zeng B., Bakshi A., Metspalu A., Dermitzakis E., Gibson G., Spector T., Montgomery G., Esko T., Visscher P. M. and Powell J. E. (2016) The genetic architecture of gene expression in peripheral blood. American Journal of Human Genetics. In Press.

Group contacts

Dr Sam Lukowski
Postdoctoral researcher
+61 7 334 62611
s.lukowski@imb.uq.edu.au
Ms Anne Senabouth
Bioinformatician
+61 7 334 62611
a.senabouth@imb.uq.edu.au
 Ms Jenny Qiao
PhD student
+61 7 334 62611
z.qiao1@uq.edu.au
Dr Emily Wong
Postdoctoral researcher
+61 7 334 62394
e.wong@imb.uq.edu.au
Ms Rebecca Lim
Research assistant
+61 7 334 62358
r.lim1@uq.edu.au
Ms Chloe Yap
Summer student and research assistant
+61 7 334 62606
c.yap@imb.uq.edu.au 
Dr Quan Nguyen
Postdoctoral researcher
+61 7 334 62394
quan.nguyen@imb.uq.edu.au
Ms Anita Goldinger
PhD student

Ms Riddhima Mater
Summer student
+61 7 334 62611
riddhima.mathur@uqconnect.edu.au  

 

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