IMB’s Mass Spectrometry Facility is home to a suite of state-of-the-art mass spectrometry, high-performance liquid chromatography, and robotic instrumentation that have been refined and optimised to investigate biological systems in a high-throughput qualitative and quantitative manner.

The 11 available systems within the facility provide researchers with the resources to investigate a broad range of mass spectrometric applications, including molecular discovery, identification, characterisation and quantification.

In 2013, the facility provided technical advice, and research and training support for 125 unique users from across South-East Queensland working on a diverse range of projects. This support ranged from concept through experimental approach, design, methodology, data acquisition, data processing, and project reporting and publication.

Through the use of this facility, our scientists hope to gain new insights into protein interactions and structures; amino acid sequence; post-translational modifications; compound stability; and bioavailability of potential therapeutics in a range of biological systems.

Some of the discoveries made in 2013 using the facility included the identification and characterisation of potential therapeutic molecules from natural product extracts using de-novo peptide sequencing; and revealing the quantitative bioavailability characteristics of new molecules in the discovery and development of potential therapeutic molecules for a number of targeted diseases, including chronic pain, breast and ovarian cancer and chronic kidney disease. The implementation of new technology in the facility, such as the nano-HPLC-AB SCIEX Triple TOF 5600, has allowed users to study complex biological systems—for example, those found in cone snail venom—in greater depth and with greater sensitivity.

The facility acknowledges funding from ARC LIEF Project LE110100186.

 

Facility contacts

Facility Manager: Alun Jones
Email: a.jones@imb.uq.edu.au
Phone: +61 7 3346 2996
Bio: Alun has more than 28 years of experience in biological mass spectrometry in both academia and industry in the UK, Canada and USA. During this time, he has developed HPLC-mass spectrometry interfaces, methods of analysis for natural products, drug and pesticide analysis, peptide and protein analysis.

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