<b>Professor Matt Cooper</b><br>
Group Leader, Chemistry and Structural Biology Division<br>
Director, IMB Centre for Superbug Solutions <br>
Investigator, IMB Centre for Pain Research<p>
P: +61 7 3346 2044<br>
E: m.cooper@imb.uq.edu.au<p>
- superbugs<br>
- antibiotics<br>
- inflammation<br>
- drug discovery<br>
- drug development<br>
- cancer<br>
- viral/bacterial infections<br>
- tuberculosis<br>
- dengue fever<br>
- Parkinson's disease
Professor Matt Cooper
Group Leader, Chemistry and Structural Biology Division
Director, IMB Centre for Superbug Solutions
Investigator, IMB Centre for Pain Research

P: +61 7 3346 2044
E: m.cooper@imb.uq.edu.au

- superbugs
- antibiotics
- inflammation
- drug discovery
- drug development
- cancer
- viral/bacterial infections
- tuberculosis
- dengue fever
- Parkinson's disease

Professor Matthew Cooper is CEO of Inflazome Ltd. and has an equity interest in the company of which UQ is also a shareholder through its commercialisation company UniQuest Pty. Ltd.

Inflazome Ltd. is a company headquartered in Dublin, Ireland that is developing drugs to address clinical unmet needs in inflammatory disease by targeting the inflammasome.

Professor Cooper also holds a fractional Professorial Research Fellow appointment at the University of Queensland.

The terms of this arrangement have been reviewed and approved by the University of Queensland, in accordance with its conflict of interest policies.

Visit the Cooper Group website for more information.

Visit the CO-ADD website for more information.

Drugs and diagnostics for superbugs, viruses and cancer

We believe we can more effectively treat patients by improving the way we understand and diagnose disease.

Our research is aimed at discovering new ways of detecting and treating bacterial infections, inflammatory disease and cancer.

We are designing and developing novel antibiotics active against drug-resistant bacteria, known as superbugs.

The alarming growth of superbugs, coupled with the paucity of companies working in this area, gives impetus to this research and our work to inform the community of these important health issues through the media.

We also work on tuberculosis and dengue fever, diseases responsible for millions of deaths in the developing world.

Our research is leading to new ways to diagnose infections caused by bacteria and viruses, and a deeper understanding of the molecular mechanisms that lead to the evolution and spread of drug resistance.

Many of our researchers have significant experience in both academia and industry, with past projects leading to products on the market today. We collaborate with government agencies and pharmaceutical, biotechnology and medical device companies in Australia, Asia, the UK and the US. We have a strong translational focus and aim to deliver innovative solutions for unmet medical needs in the community.

During the past 12 months, we have gained a deeper understanding of the role of gut biota, which are the bacteria that live in our digestive system, and how this affects inflammation in the development of diseases such as asthma, chronic obstructive pulmonary disease, diabetes and cancer. This basic research helps us to develop new methods to diagnose and more effectively treat patients affected by these complex and deadly diseases.

Furthermore, in partnership with more than 12 laboratories worldwide, we are designing and developing new molecules to target the interface between infection and our immune system’s response that leads to acute and chronic inflammatory disease. 

Make a difference to Professor Cooper's research by donating today.

Research in the news

Click here to view recent media coverage of Cooper Lab's research. 

December 2015: The year’s leaders in the arts, sciences, fashion, food, education and ideas (behind paywall) via QWeekend’s 50 Best and Brightest, The Courier-Mail

December 2015: UQ crowdsourcing the next antibiotic to combat superbugs via Advance Queensland Innovators website

September 2015: When should you take antibiotics via The Conversation

July 2015: Resistance isn’t futile – how to tackle drug-resistant superbugs via The Guardian

20 November 2014 Lifesaving antibiotics losing effectiveness via 7 News 

3 March 2014 - Researchers aim to stamp out superbugs via 7 News Brisbane 

Cooper Group projects and opportunities

You can view current Cooper Lab research projects and opportunities here or via IMB's postgraduate website

Key publications

View more publications by Professor Cooper via Pubmed or via UQ Researchers. 

“A community-based approach to new antibiotic discovery”, Matthew A Cooper, Nature Reviews Drug Discovery, 2015, DOI: 10.1038/nrd4706

“Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity” J. Zuegg , C. Muldoon, G. Adamson, D. McKeveney, G.L. Thanh, R. Premraj, B. Becker, M. Cheng, A. Elliott , J. Huang, M.S. Butler, M. Bajaj, J. Seifert, L. Singh, N. Galley, D. Roper, A. Lloyd, C. Dowson, T.-J. Cheng, W.-C. Cheng, D. Demon, E. Meyer, W. Meutermans and M.A. Cooper. Nature Communications, 2015. DOI: 10.1038/ncomms8719

“A small molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases,” R.C. Coll, A.A.B. Robertson, J.J. Chae, S.C.. Higgins, R. Muñoz-Planillo, M.C.. Inserra, I. Vetter, L.S.. Dungan, B.G.. Monks, A. Stutz, D.E. Croker, M.S. Butler, M. Haneklaus, C.E. Sutton, G. Núñez, E. Latz, D.L. Kastner, K.H.G. Mills, S.L. Masters, K. Schroder, MA Cooper, L.A.J. O’Neill, Nature Medicine, 2015, 21, 248-255 DOI: 10.1038/NM.3806

"Emerging pathogenic links between microbiota and the gut-lung axis", Budden KF, Gellatly SL, Wood DL, Cooper MA, Morrison M, Hugenholtz P, Hansbro PM, Nature Rev Microbiol., 2016, DOI: 10.1038/nrmicro.2016.142

"IL-1β is an innate immune sensor of microbial proteolysis", Christopher N. LaRock, Jordan Todd, Doris L. LaRock, Joshua Olson, Avril A. Robertson, Matthew A. Cooper, Hal M. Hoffman, Victor Nizet, Science Immunology, 2016, 1 (2), pp.eaah3539, DOI: 10.1126/sciimmunol.aah3539

"T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells", Giuseppina Arbore, Erin E West, Avril A Robertson, Andreas Klos, Trent Woodruff, Luke A O'Neill, Alan Sher, Warren Leonard, Pete Monk, Matthew A Cooper, Andrew Cope, Katrin Mayer-Barber, Helen J Lachmann, Claudia Kemper, Science, 2016, 352 (6292),
DOI: 10.1126/science.aad1210

Group contacts

Professor Matt Cooper
Group leader
+61 7 334 62044

Dr Alysha Elliott
Research staff
+61 7 334 62745
Dr Alejandra Gallardo-Godoy
Research staff
+61 7 334 62745
Ms Angela Kavanagh
Research staff
+61 7 334 62398
Dr Avril Robertson
Research staff
+61 7 334 62204
Mrs Danielle Sutherland
Support staff
+61 7 334 62745
Mr David Edwards
Research staff
+61 7 334 62067
Mrs Emma Cowie
Support staff
+61 7 334 62389
Ms Janet Reid
Research staff
+61 7 334 62399
Dr Johannes Zuegg
Research staff
+61 7 334 62994
Dr Karl Hansford
Research staff
+61 7 334 62107
Ms Maite Amado
Research staff
+61 7 334 62399

Dr Mark Butler
Research staff
+61 7 334 62992

Dr Mark Blaskovich
Research staff
+61 7 334 62966
Ms Mathilde Desselle
Support staff
+61 7 334 62746
Ms Ruby Pelingon
Research staff
+61 7 334 62371
Ms Ruth Neale
Support staff
+61 7 334 62389
Ms Soumya Ramu
Research staff
+61 7 334 62399
Dr Zyta Ziora
Research staff
+61 7 334 62067
Mr Alexander Booy
Research higher degree student
+61 7 334 62375

Ms Amy Chan
Research higher degree student
+61 7 334 62375

Ms Angie Jarrard
Research higher degree student
+61 7 334 62107
Mrs Anggia Prasetyoputri
Research higher degree student
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Research higher degree student
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Mr James Hill
Research higher degree student
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Ms Karlee Rees
Research higher degree student
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Mr Lalith Kummari
Research higher degree student
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Research higher degree student
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Research higher degree student
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Research higher degree student
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Research higher degree student
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Mr Sanjaya Kc
Research higher degree student
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Ms Wanida Phetsang
Research higher degree student
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Mrs Zoe Schofield
Research higher degree student
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