Cell Biology and Molecular Medicine
IMB’s Cell Biology and Molecular Medicine Division seeks to understand the molecular workings of the cell, the building blocks of our bodies. This is vital for a full understanding of how our bodies function, and serves as a foundation to investigate the cellular basis of disease.
IMB scientists are tackling key issues in cell biology, investigating the mechanisms responsible for how cells develop, function, move and interact with one another. Laboratories within the division regularly work alongside collaborators from other research disciplines, where a multidisciplinary approach is necessary to solve fundamental problems or build new technologies.
During 2013, the division supported research in the following areas:
- cadherin cell-cell adhesion and tissue organisation in health and disease
- molecular engineering: better tools, better science, better life
- membrane trafficking at atomic resolution
- role of the cell surface in health and disease
- protein trafficking and inflammation
- role of growth hormone in human development
- endosomal dynamics and pathogen invasion
- infection and innate immunity
- inflammation and innate immunity.
Many leading technologies are used to help the division advance discoveries in these areas, with state-of-the-art, on-site facilities for quantitative optical microscopy, live cell imaging, single-molecule protein interaction analysis, and protein structure determination.
Notably, the division is closely allied with the Australian Microscopy and Microanalysis Research Facility, which allows for the application of cryo-electronic microscopy, cellular tomography, advanced visualisation and high-performance computing. Members of the division also oversee the Australian Cancer Research Foundation’s Cancer Biology Imaging Facility.
|Professor Alpha Yap||Division Head||Cadherin cell-cell adhesion and tissue organisation in health and disease||cell-cell adhesion; cytoskeleton; epithelial morphogenesis; breast cancer; bowel cancer; wound healing; epithelial inflammation|
|Professor Kirill Alexandrov||Group Leader||Molecular engineering: better tools, better science, better life||cancer; blindness; thrombosis; excessive bleeding|
|Associate Professor Brett Collins||Group Leader||Membrane trafficking at atomic resolution||Alzheimer's disease; Parkinson's disease; inflammation; cancer|
|Professor George Muscat||Group Leader||Nuclear hormone receptors and metabolic disease||type 2 diabetes; obesity; breast cancer; melanoma|
|Professor Rob Parton||Group Leader||Role of the cell surface in health and disease||cancer; muscular dystrophy; diabetes; lipodystophy|
|Professor Jenny Stow||IMB Deputy Director (Research) and Group Leader||Protein trafficking and inflammation||inflammation; inflammatory diseases; bacteria and infection; macrophage biology; cancer|
|Associate Professor Rohan Teasdale||Group Leader||Endosomal dynamics and pathogen invasion||infectious disease; Salmonella bacteria; Alzheimer's disease; Parkinson's disease|
|Professor Matt Sweet||Group Leader||Infection and innate immunity||innate immunity; inflammatory disease; rheumatoid arthritis; atherosclerosis; infectious disease; salmonellosis; urinary tract infections; cancer|
|Dr Kate Schroder||Group Leader||Inflammasomes: mediators of immune defence but culprits in inflammatory disease||innate immunity; inflammasome; Salmonella bacteria; hereditary disease; diabetes; arthritis; gout|